BDBM50475233 CHEMBL191091

SMILES CC(C)C(C(=O)Nc1ccc(cc1)C(=O)NO)c1ccccc1

InChI Key InChIKey=LAMIXXKAWNLXOC-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50475233   

TargetHistone deacetylase(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50475233(CHEMBL191091)
Affinity DataIC50: 30nMAssay Description:In vitro inhibitory concentration against histone deacetylase of DU-145 prostate cell nuclear extract as deacetylation of biotinylated [3H]-acetyl hi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50475233(CHEMBL191091)
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50475233(CHEMBL191091)
Affinity DataIC50: 44nMAssay Description:Inhibition of human recombinant HDAC2 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50475233(CHEMBL191091)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant HDAC3 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50475233(CHEMBL191091)
Affinity DataIC50: 87nMAssay Description:Inhibition of human recombinant HDAC8 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50475233(CHEMBL191091)
Affinity DataIC50: 770nMAssay Description:Inhibition of human recombinant HDAC7 pre-incubated for 15 mins before Ac-Leu-Gly-Lys(trifluroAc)-AMC substrate addition and measured after 60 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50475233(CHEMBL191091)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of HDAC1 in human MM96L cells assessed as activation of histone H4 acetylation at Lys5, Lys8, Lys12 and Lys16 residues by Western blot ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed