BDBM50473685 CHEMBL76297

SMILES CNC(=O)[C@@H](NC(=O)[C@@H]([C@H](CO)C(=O)NO)c1ccccc1)C(C)(C)C

InChI Key InChIKey=GKLAUAGSCYZMQP-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50473685   

TargetTumor necrosis factor(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataIC50: 928nMAssay Description:Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataKi:  3.5nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataKi:  4.80nMAssay Description:Inhibitory potency against Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataKi:  4.90nMAssay Description:Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataKi:  13nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed