BDBM50468575 CHEMBL2312139

SMILES c1ccc(cc1)CNC(=O)N2CCC(=O)N3[C@@H]2CN(C(=O)[C@@H]3Cc4ccc(cc4)O)Cc5cccc6c5cccc6

InChI Key InChIKey=HQWTUOLCGKIECB-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50468575   

TargetCREB-binding protein(Human)
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50468575(CHEMBL2312139)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CBP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50468575(CHEMBL2312139)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of beta-Catenin/TCF4 (unknown origin) protein-protein interaction by TOPFLASH reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetB-cell CLL/lymphoma 9 protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50468575(CHEMBL2312139)
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of beta-catenin/BCL9 protein-protein interaction in Wnt-dependent human HCT-116 cells assessed as reduction in Axin2 expression level by q...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetB-cell CLL/lymphoma 9 protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50468575(CHEMBL2312139)
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of beta-catenin/BCL9 protein-protein interaction in Wnt-dependent human SW480 cells assessed as reduction in Axin2 expression level by qRT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetB-cell CLL/lymphoma 9 protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50468575(CHEMBL2312139)
Affinity DataIC50: 2.47E+4nMAssay Description:Inhibition of beta-catenin/BCL9 protein-protein interaction in Wnt-independent human A549 cells assessed as reduction in Axin2 expression level by qR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetB-cell CLL/lymphoma 9 protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50468575(CHEMBL2312139)
Affinity DataIC50: 2.63E+4nMAssay Description:Inhibition of beta-catenin/BCL9 protein-protein interaction in Wnt-independent human RKO cells assessed as reduction in Axin2 expression level by qRT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetB-cell CLL/lymphoma 9 protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50468575(CHEMBL2312139)
Affinity DataIC50: 3.83E+4nMAssay Description:Inhibition of beta-catenin/BCL9 protein-protein interaction in Wnt-independent human HEK293 cells assessed as reduction in Axin2 expression level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50468575(CHEMBL2312139)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of beta catenin/Tcf4 (unknown origin) protein protein interaction measured after 24 hrs by TOP-flash luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50468575(CHEMBL2312139)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of beta-catenin/Tcf4 (unknown origin) in human SW480 cells assessed as reduction in cyclin D1 level qRT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed