BDBM50468565 CHEMBL4277125

SMILES COc1cccc(c1)C1=NN(C(C1)c1ccc2OCCOc2c1)C(=S)Nc1ccccc1

InChI Key InChIKey=FIVPBDOYVACZJP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50468565   

TargetMitogen-activated protein kinase 8(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50468565(CHEMBL4277125)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of N-terminal flag-tagged JNK1 (unknown origin) expressed in baculovirus expression system after 60 mins in presence of [gamma-32P]ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50468565(CHEMBL4277125)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of recombinant human GST-tagged c-RAF (306 to 648 residues) Y340D/Y341D mutant expressed in baculovirus expression system using recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50468565(CHEMBL4277125)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of N-terminal flag-tagged p38alpha (unknown origin) expressed in baculovirus expression system using MBP as substrate preincubated for 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50468565(CHEMBL4277125)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50468565(CHEMBL4277125)
Affinity DataIC50: 1.95E+5nMAssay Description:Inhibition of MEK1/2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Mouse)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50468565(CHEMBL4277125)
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed