BDBM50468408 CHEMBL4278642::US11834432, Compound S11

SMILES CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)N4CCN(CCO)CC4)c3)ccc12

InChI Key InChIKey=AISWQGLURAAAKE-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50468408   

TargetFibroblast growth factor receptor 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA based spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 10nMAssay Description:1. Enzyme reaction substrate μPoly(Glu,Tyr)4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant FGFR2 (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of recombinant FGFR3 (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of recombinant VEGFR1 (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant PDGFRalpha (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50468408(CHEMBL4278642 | US11834432, Compound S11)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of recombinant PDGFRbeta (unknown origin) incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed