BDBM50467750 CHEMBL4279519

SMILES COc1c2CCOc2c(Cc2ccc3OCCOc3c2)cc1[C@@H]1O[C@H](CO)[C@@H](F)[C@H](O)[C@H]1O

InChI Key InChIKey=QUHJWCHBJBZVQP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50467750   

TargetSodium/glucose cotransporter 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50467750(CHEMBL4279519)
Affinity DataIC50: 43nMAssay Description:Inhibition of human small intestinal SGLT1 expressed in CHOK1 cells assessed as reduction in Na-dependent [14C]-AMG uptake preincubated for 10 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50467750(CHEMBL4279519)
Affinity DataIC50: 68nMAssay Description:Inhibition of rat SGLT1 expressed in CHOK1 cells assessed as reduction in Na-dependent [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50467750(CHEMBL4279519)
Affinity DataIC50: 16nMAssay Description:Inhibition of rat SGLT2 expressed in CHOK1 cells assessed as reduction in Na-dependent [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50467750(CHEMBL4279519)
Affinity DataIC50: 9nMAssay Description:Inhibition of human kidneyl SGLT2 expressed in CHOK1 cells assessed as reduction in Na-dependent [14C]-AMG uptake preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed