BDBM50466969 CHEMBL4287442::US10668067, Example 1-4

SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=GDIYUWJYYJYPJH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50466969   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50466969(CHEMBL4287442 | US10668067, Example 1-4)
Affinity DataIC50: 33nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 3 mins by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50466969(CHEMBL4287442 | US10668067, Example 1-4)
Affinity DataIC50: 33nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent