BDBM50466825 CHEMBL4290222

SMILES CC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnn2ccc(C3CCOCC3)c12

InChI Key InChIKey=SWPXADMCNLNAGW-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50466825   

TargetDual specificity protein kinase CLK4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 99nMAssay Description:Inhibition of recombinant human full length GST-tagged CLK4 expressed in baculovirus expression system in presence of 5 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 99nMAssay Description:Inhibition of human CLK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 39nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 786nMAssay Description:Inhibition of human CLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 10nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 93nMAssay Description:Inhibition of recombinant full length His-tagged human IRAK4 expressed in baculovirus expression system using 5-FAM-IPTSPITTTYFFFKKK-COOH as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 94nMAssay Description:Inhibition of recombinant full length His-tagged human IRAK4 expressed in baculovirus expression system using 5-FAM-IPTSPITTTYFFFKKK-COOH as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 1.89E+3nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged full length CDK9/untagged full length Cyclin T1 expressed in baculovirus infected Sf21 insect ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-C(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 111nMAssay Description:Inhibition of recombinant human full length His-tagged CDK8/cyclin C expressed in baculovirus expression system in presence of 5 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 516nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK7/recombinant full length untagged cyclin H/recombinant full length N-terminal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 786nMAssay Description:Inhibition of recombinant human GST-tagged CLK1 catalytic domain (129 to 484 residues) expressed in Escherichia coli expression system in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged CLK3 expressed in baculovirus expression system in presence of 150 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 72nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged IRAK1 (194 to end residues) expressed in baculovirus infected Sf21 insect cells in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 94nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length IRAK4 expressed in baculovirus infected Sf21 insect cells in presence of 5000 uM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 420nMAssay Description:Inhibition of IRAK4 in human KARPAS299 cells assessed as reduction in IL-1 stimulated IRAK4 phosphorylation at Thr345/Ser346 residues preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged full length CDK9/untagged full length Cyclin T1 expressed in baculovirus infected Sf21 insect ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human GST-tagged CLK2 catalytic domain (137 to 498 residues) expressed in baculovirus expression system in presence of 25 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 417nMAssay Description:Inhibition of IRAK4 in human KARPAS299 cells assessed as reduction in IL-1 stimulated IRAK4 phosphorylation at Thr345/Ser346 residues preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK7/recombinant full length untagged cyclin H/recombinant full length N-terminal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed