BDBM50466824 CHEMBL4278882

SMILES CC(C)c1ccn2ncnc(N[C@H]3CC[C@@H](CC3)N3CCN(CC3)C(C)=O)c12

InChI Key InChIKey=FQBRQRVXPUQKLG-UHFFFAOYSA-N

Data  18 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50466824   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length IRAK4 expressed in baculovirus infected Sf21 insect cells in presence of 5000 uM A...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant human full-length His-tagged IRAK4 expressed in baculovirus expression system using 5-FAM-IPTSPITTTYFFFKKK-COOH as substrat...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/28/2022
Entry Details Article
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TargetInterleukin-1 receptor-associated kinase 3(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 31nMAssay Description:Inhibition of kinase tracer 236 binding to recombinant human full-length GST-tagged IRAK3 expressed in insect cells by Lanthascreen Eu kinase binding...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/28/2022
Entry Details Article
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TargetInterleukin-1 receptor-associated kinase 1(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged IRAK1 (194 to 712 residues) expressed in baculovirus expression system using 5-FAM-KKKVSRSGLYRS...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/28/2022
Entry Details Article
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TargetInterleukin-1 receptor-associated kinase 1(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged IRAK1 (194 to end residues) expressed in baculovirus infected Sf21 insect cells in presence of...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged full length CDK9/untagged full length Cyclin T1 expressed in baculovirus infected Sf21 insect ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
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TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK7/recombinant full length untagged cyclin H/recombinant full length N-terminal ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
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TargetDual specificity protein kinase CLK4(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 147nMAssay Description:Inhibition of recombinant human full length GST-tagged CLK4 expressed in baculovirus expression system in presence of 5 uM ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
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TargetDual specificity protein kinase CLK1(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 502nMAssay Description:Inhibition of recombinant human GST-tagged CLK1 catalytic domain (129 to 484 residues) expressed in Escherichia coli expression system in presence of...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
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TargetDual specificity protein kinase CLK3(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged CLK3 expressed in baculovirus expression system in presence of 150 uM ATPMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 195nMAssay Description:Inhibition of IRAK4 in human KARPAS299 cells assessed as reduction in IL-1 stimulated IRAK4 phosphorylation at Thr345/Ser346 residues preincubated fo...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant full length His-tagged human IRAK4 expressed in baculovirus expression system using 5-FAM-IPTSPITTTYFFFKKK-COOH as substrat...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
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TargetCyclin-C(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 43nMAssay Description:Inhibition of recombinant human full length His-tagged CDK8/cyclin C expressed in baculovirus expression system in presence of 5 uM ATPMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant full length His-tagged human IRAK4 expressed in baculovirus expression system using 5-FAM-IPTSPITTTYFFFKKK-COOH as substrat...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetDual specificity protein kinase CLK2(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 175nMAssay Description:Inhibition of recombinant human GST-tagged CLK2 catalytic domain (137 to 498 residues) expressed in baculovirus expression system in presence of 25 u...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
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TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK7/recombinant full length untagged cyclin H/recombinant full length N-terminal ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 195nMAssay Description:Inhibition of IRAK4 in human KARPAS299 cells assessed as reduction in IL-1 stimulated IRAK4 phosphorylation at Thr345/Ser346 residues preincubated fo...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50466824(CHEMBL4278882)Copy SMILESCopy InChI

Affinity DataIC50: 890nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged full length CDK9/untagged full length Cyclin T1 expressed in baculovirus infected Sf21 insect ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL