BDBM50466804 CHEMBL4289017

SMILES CC(=O)NCC(=O)N1[C@H]2CC[C@@H]1c3c2ccc(c3)Nc4ncc(c(n4)NC5CCC5)C(F)(F)F

InChI Key InChIKey=RYYNGWLOYLRZLK-UHFFFAOYSA-N

Data  7 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50466804   

TargetAurora kinase B(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM50466804(CHEMBL4289017)
Affinity DataIC50: 5nMAssay Description:Inhibition of full-length His-tagged recombinant aurora B (unknown origin) expressed in insect cells using biotinylated LRRWSLG substrate by scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM50466804(CHEMBL4289017)
Affinity DataIC50: 20nMAssay Description:Inhibition of aurora A in human MDA-MB-231 cells assessed as reduction in enzyme autophosphorylation incubated for 4 hrs by high-content immunofluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM50466804(CHEMBL4289017)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of full-length His-tagged recombinant aurora A (unknown origin) expressed in insect cells using biotinylated LRRWSLG substrate by Z'-LYTE ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM50466804(CHEMBL4289017)
Affinity DataIC50: 11nMAssay Description:Inhibition of aurora B in human MDA-MB-231 cells assessed as reduction in enzyme autophosphorylation incubated for 4 hrs by high-content immunofluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM50466804(CHEMBL4289017)
Affinity DataIC50: 50nMAssay Description:Inhibition of aurora B in human MDA-MB-231 cells assessed as reduction in phosphorylation of histone H3 on Ser10 incubated for 4 hrs by high-content ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM50466804(CHEMBL4289017)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant full-length His-tagged Aurora A (unknown origin) expressed in insect cells using biotinylated LRRWSLG as substrate in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM50466804(CHEMBL4289017)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant full-length His-tagged Aurora B (unknown origin) expressed in insect cells using biotinylated LRRWSLG as substrate measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed