BDBM50466671 CHEMBL4277610

SMILES Fc1cccc(c1)S(=O)(=O)N[C@@H]1C[C@H](NC#N)c2cc(ccc12)-c1ncnc2[nH]ccc12

InChI Key InChIKey=MLJSOTTYIVCEQO-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50466671   

TargetTyrosine-protein kinase TXK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TXK (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 331nMAssay Description:Inhibition of His-tagged human recombinant JAK3 (781 to 1124 residues) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 3.01E+3nMAssay Description:Inhibition of recombinant human GST-tagged JAK2 using KAIETDKEYYTVKD-NH2 as substrate in presence of 1 mM ATP concentration by coupled PK/LDH assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human GST-tagged JAK3 JH1 domain using KAIETDKEYYTVKD-NH2 as substrate in presence of 1 mM ATP concentration by coupled PK/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER4 (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER2 (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 3.39E+3nMAssay Description:Inhibition of BMX (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK1/TYK2 in human PBMC assessed as reduction in IL10-induced STAT3 phosphorylation preincubated for 75 mins followed by IL10 addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 331nMAssay Description:Inhibition of JAK3 in human PBMC assessed as reduction in IL15-induced STAT5 phosphorylation preincubated for 75 mins followed by IL15 addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human His-tagged TYK2 expressed in SF21/baculovirus expression system using KAIETDKEYYTVKD-NH2 as substrate in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of recombinant human GST-tagged JAK1 using KAIETDKEYYTVKD-NH2 as substrate in presence of 1 mM ATP concentration by coupled PK/LDH assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TEC (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAP2K7 (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ITK (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BLK (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50466671(CHEMBL4277610)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 in human whole blood assessed as reduction in IL15-induced STAT5 phosphorylation preincubated for 75 mins followed by IL15 additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed