BDBM50466367 CHEMBL4290041

SMILES CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(F)c2)C(C)(C)C(=O)Nc2ccc(F)cc2)cc1

InChI Key InChIKey=JCIWZUTVGHDCLP-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50466367   

TargetOxysterols receptor LXR-alpha(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466367(CHEMBL4290041)
Affinity DataEC50: >3.00E+4nMAssay Description:Transrepression of recombinant human GAL4-DBD fused LXRalpha LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466367(CHEMBL4290041)
Affinity DataIC50: 25nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Mouse)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466367(CHEMBL4290041)
Affinity DataIC50: 420nMAssay Description:Transrepression of RORgammat in anti-CD3/CD28 stimulated C57BL/6 mouse CD4-positive T cells assessed as suppression of T cell differentiation to Th17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Mouse)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466367(CHEMBL4290041)
Affinity DataIC50: 250nMAssay Description:Transrepression of recombinant mouse GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466367(CHEMBL4290041)
Affinity DataIC50: 1.00E+4nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORbeta LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466367(CHEMBL4290041)
Affinity DataEC50: >3.00E+4nMAssay Description:Transrepression of recombinant human GAL4-DBD fused LXRbeta LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466367(CHEMBL4290041)
Affinity DataIC50: 30nMAssay Description:Displacement of [3H]-Digoxin from recombinant human GST-fused RORgammat LBD after 1 to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466367(CHEMBL4290041)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]T0901317 from recombinant human GST-fused RORalpha LBD after 1 to 4 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed