BDBM50466321 CHEMBL4285813

SMILES C[C@H]1CN(C[C@@H](C)O1)c1ccc(Nc2nc(N3CC[C@@H](C3)NC(=O)C=C)c(F)cc2C(N)=O)cc1

InChI Key InChIKey=UMZLBMHXTFHHHS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50466321   

TargetTyrosine-protein kinase BTK(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50466321(CHEMBL4285813)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged BTK (2 to 659 residues) expressed in baculovirus expression system using FITC-AHA-E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50466321(CHEMBL4285813)
Affinity DataIC50: 14nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human PBMC assessed as suppression of BCR-induced CD69 expression on B cells pretreated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed