BDBM50466296 CHEMBL4289556

SMILES Cc1noc(C)c1-c1ccc2nc(nc(N3CCOCC3c3ccccc3)c2c1)-c1cnn(CCO)c1

InChI Key InChIKey=XGGMHAKFCUIDSF-UHFFFAOYSA-N

Data  1 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50466296   

TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466296(CHEMBL4289556)
Affinity DataKd:  66nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466296(CHEMBL4289556)
Affinity DataKd:  66nMAssay Description:Binding affinity to BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466296(CHEMBL4289556)
Affinity DataKd:  66nMAssay Description:Competitive binding affinity to human partial length BRD4 (BD1,2) (N44 to E460 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466296(CHEMBL4289556)
Affinity DataIC50: 72nMAssay Description:Inhibition of human full-length recombinant N-terminal His-tagged BRD4 (2 to 1362 residues) expressed in Sf9 cells using histone H4 peptide containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed