BDBM50466038 CHEMBL4281823
SMILES CCn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc12
InChI Key InChIKey=APPXQUDJLJXULP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 53 hits for monomerid = 50466038
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataKd: 7.20E+3nMAssay Description:Binding affinity to wild-type human partial length RIPK3 (M1 to Q307 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of recombinant full length human Lck using KVEKIGEGTYGVV as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation counti...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase HCK(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 142nMAssay Description:Inhibition of recombinant human Hck (230 to 497 residues) using KVEKIGEGTYGVV as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillat...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 387nMAssay Description:Inhibition of recombinant human GCK (1 to 473 residues) using myelin basic protein as substrate after 40 mins in presence of [gamma-33P]-ATP by scint...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human Flt4 V1128L/H1146R double mutant (800 to end residues) using KKKSPGEYVNIEF as substrate after 40 mins in presence of ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 127nMAssay Description:Inhibition of recombinant human FGFR1 (456 to 765 residues) using KKKSPGEYVNIEF as substrate after 40 mins in presence of [gamma-33P]-ATP by scintill...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibition of recombinant human FAK (411 to 686 residues) using EEEEYEEEEEEYY as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillat...More data for this Ligand-Target Pair
TargetEphrin type-A receptor 7(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human EphA7 (613 to 909 residues) using KTFCGTPEYLAPE as substrate after 40 mins in presence of [gamma-33P]-ATP by scintill...More data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human DDR1 (492 to end residues) using KKKSPGEYVNIEF as substrate after 40 mins in presence of [gamma-33P]-ATP by scintilla...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 862nMAssay Description:Inhibition of recombinant full length human BTK using KVEKIGEGTYGVV as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation counti...More data for this Ligand-Target Pair
TargetAurora kinase B(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant full length human Aurora-B using AKRRRLSSLRA as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation cou...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL2(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 306nMAssay Description:Inhibition of recombinant human ARG (38 to end residues) using EAIYAAPFAKKK as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillatio...More data for this Ligand-Target Pair
TargetActivated CDC42 kinase 1(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 995nMAssay Description:Inhibition of recombinant human ACK1 (1 to 389 residues) using EFPIYDFLPAKKK as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillati...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 4(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to wild-type human partial length RIPK4 (M1 to V303 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 9(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant human MLK1 (134 to 414 residues) using casein as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation co...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human RIPK1 (8 to 322 residues) using myelin basic protein as substrate after 120 mins in presence of [gamma-33P]-ATP by sc...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Inhibition of recombinant full length human Lyn using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation c...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 3(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human MST2 (2 to end residues) using myelin basic protein as substrate after 40 mins in presence of [gamma-33P]-ATP by scin...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 207nMAssay Description:Inhibition of recombinant human Src (1 to 530 residues) using GGEEEEYFELVKK as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillatio...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 10(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human MLK2 (1 to 449 residues) using myelin basic protein as substrate after 40 mins in presence of [gamma-33P]-ATP by scin...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human Itk (352 to 617 residues) using myelin basic protein as substrate after 40 mins in presence of [gamma-33P]-ATP by sci...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 173nMAssay Description:Inhibition of recombinant full length human cSRC using KVEKIGEGTYGVV as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation count...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 335nMAssay Description:Inhibition of recombinant human ABL (27 to end residues) using EAIYAAPFAKKK as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillatio...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 2(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 255nMAssay Description:Inhibition of recombinant full length human MEKK2 using myelin basic protein as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillati...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of recombinant human Met A1209G/V1290L double mutant (974 to end residues) using KKKGQEEEYVFIE as substrate after 40 mins in presence of [...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 5(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant full length human MAP4K5 using myelin basic protein as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillat...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Human)
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 116nMAssay Description:Inhibition of PKR (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Inhibition of recombinant human Flt1 (783 to end residues) using KKKSPGEYVNIEF as substrate after 40 mins in presence of [gamma-33P]-ATP by scintilla...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to wild-type human partial length RIPK2 (M1 to K310 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Blk(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 138nMAssay Description:Inhibition of recombinant full length human Blk M287V mutant using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33P]-ATP by sc...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human Mer H628Q/R794A double mutant (557 to 882 residues) using GGMEDIYFEFMGG as substrate after 40 mins in presence of [ga...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fyn(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 187nMAssay Description:Inhibition of recombinant full length human Fyn using KVEKIGEGTYGVV as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation counti...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Yes(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 384nMAssay Description:Inhibition of recombinant full length human Yes using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation c...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fgr(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 470nMAssay Description:Inhibition of recombinant human Fgr (2 to end residues) using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33P]-ATP by scintil...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 20(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 457nMAssay Description:Inhibition of recombinant full length human ZAK using MBP as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation counting analysi...More data for this Ligand-Target Pair
TargetEphrin type-A receptor 2(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 341nMAssay Description:Inhibition of recombinant human EphA2 (596 to 900 residues) using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33P]-ATP by sci...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK3(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 97nMAssay Description:Inhibition of recombinant human WNK3 (1 to 434 residues) using myelin basic protein as substrate after 40 mins in presence of [gamma-33P]-ATP by scin...More data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant human Tie2 Q939H/Q940H double mutant (771 to end residues) using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 268nMAssay Description:Inhibition of recombinant full length human NEK2 using myelin basic protein as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillatio...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human HRI (140 to end residues) using RSRSRSRSRSRSR as substrate after 120 mins in presence of [gamma-33P]-ATP by scintilla...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 182nMAssay Description:Inhibition of recombinant human cKit (544 to end residues) using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33P]-ATP by scin...More data for this Ligand-Target Pair
TargetEphrin type-A receptor 8(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 233nMAssay Description:Inhibition of recombinant human EphA8 (615 to 911 residues) using KTFCGTPEYLAPE as substrate after 40 mins in presence of [gamma-33P]-ATP by scintill...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human Axl Q764R mutant (473 to end residues) using KKSRGDYMTMQIG as substrate after 40 mins in presence of [gamma-33P]-ATP ...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataKd: 4.40nMAssay Description:Binding affinity to wild-type human partial length RIPK1 (M1 to K305 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 106nMAssay Description:Inhibition of recombinant human MAP4K3 (1 to 291 residues) using RLGRDKYKTLRQI as substrate after 40 mins in presence of [gamma-33P]-ATP by scintilla...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 116nMAssay Description:Inhibition of recombinant human DDR2 S642A mutant (467 to end residues) using KKSRGDYMTMQIG as substrate after 40 mins in presence of [gamma-33P]-ATP...More data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 6(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 111nMAssay Description:Inhibition of recombinant full length human BRK using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation c...More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human TrkC (510 to end residues) using GEEPLYWSFPAKK as substrate after 40 mins in presence of [gamma-33P]-ATP by scintilla...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human TrkB (455 to end residues) using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33P]-ATP by scin...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Human)
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human TrkA (440 to end residues) using KKKSPGEYVNIEF as substrate after 40 mins in presence of [gamma-33P]-ATP by scintilla...More data for this Ligand-Target Pair