BDBM50465797 CHEMBL4280661

SMILES COc1ccccc1-n1nc(cc1-c1ccnc(Cl)c1)C1CC(C)(C)OC(C)(C)C1

InChI Key InChIKey=CJDSBQWZSGFNTC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50465797   

TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465797(CHEMBL4280661)
Affinity DataIC50: 250nMAssay Description:Inhibition of high frequency stimulation-induced Cav2.2 (unknown origin) expressed in HEK293 cells at -80 mV holding membrane potential by automated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465797(CHEMBL4280661)
Affinity DataIC50: 740nMAssay Description:Inhibition of low frequency stimulation-induced Cav2.2 (unknown origin) expressed in HEK293 cells at -80 mV holding membrane potential by automated p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465797(CHEMBL4280661)
Affinity DataIC50: 11nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed