BDBM50465718 CHEMBL4294493

SMILES C[C@H](NC(=O)N(C)C1CCN(CC1)C1CCc2cc(ccc12)-c1cc(C)ncn1)c1ccc(-c2cnccn2)c(Cl)c1Cl

InChI Key InChIKey=RUUCIUOBMJBNIZ-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50465718   

TargetGrowth hormone secretagogue receptor type 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50465718(CHEMBL4294493)
Affinity DataIC50: 369nMAssay Description:Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50465718(CHEMBL4294493)
Affinity DataEC50:  194nMAssay Description:Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50465718(CHEMBL4294493)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as induction of intracellular calcium release after 15 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed