BDBM50465503 CHEMBL4277456

SMILES CNS(=O)(=O)c1ccc(CCNC(=O)c2cc(Cl)ccc2OC)cc1

InChI Key InChIKey=LXYPQRJNQPYTQW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50465503   

LigandPNGBDBM50465503(CHEMBL4277456)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of NLRP3 in mouse J774A.1 cells assessed as reduction in LPS-stimulated IL-1beta levels pre-incubated with LPS for 4.5 hrs followed by inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50465503(CHEMBL4277456)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of NLRP3 (unknown origin) assessed as reduction of IL-1beta productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50465503(CHEMBL4277456)
Affinity DataIC50: 3.21E+3nMAssay Description:Inhibition of NLRP3 inflammasome in mouse JJ74.A1 cells assessed as inhibition of LPS/ATP-induced IL-1 beta release stimulated with LPS for 4.5 hs fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed