BDBM50465081 CHEMBL4294122

SMILES COc1ccc2c(NC3CCN(Cc4ccccc4)CC3)nc(NCCNC(=O)CCCCCC(=O)NO)nc2c1

InChI Key InChIKey=AWFJKIGLLSWFNV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50465081   

TargetHistone deacetylase(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50465081(CHEMBL4294122)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of HDAC in human HeLa cells using Boc-K(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50465081(CHEMBL4294122)
Affinity DataIC50: 5.74E+3nMAssay Description:Inhibition of HDAC in human K562 cells using Boc-K(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50465081(CHEMBL4294122)
Affinity DataIC50: 7.14E+3nMAssay Description:Inhibition of G9a in human MDA-MB-231 cells assessed as reduction in H3K9me2 level after 2 days by immunofluorescence in-cell western analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50465081(CHEMBL4294122)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC in human A549 cells using Boc-K(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Mouse)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50465081(CHEMBL4294122)
Affinity DataIC50: 7.14E+3nMAssay Description:Inhibition of mouse thymus 6His-sumo-tagged G9a (969 to 1263 residues) expressed in Escherichia coli BL21 (DE3) using histone H3 as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50465081(CHEMBL4294122)
Affinity DataIC50: 5.74E+3nMAssay Description:Inhibition of HDAC in human HeLa cells using BOC-K(Ac)-AMC as substrate preincubated for 3 hrs followed by substrate addition and measured after 3 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed