BDBM50465063 CHEMBL4287506::US10550080, Example 45

SMILES CC(C)COc1ccc(cn1)-c1cn(C)c2cc(C(=O)NS(=O)(=O)C3CC3)c(F)cc12

InChI Key InChIKey=HVSCJBAXISNDCU-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50465063   

TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465063(CHEMBL4287506 | US10550080, Example 45)
Affinity DataIC50: 26nMAssay Description:Displacement of [3H]-labelled radioligand from human Nav1.7 expressed in HEK293 cells measured after 24 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465063(CHEMBL4287506 | US10550080, Example 45)
Affinity DataIC50: 59nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells at -60 mV holding potential measured after 600 secs by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465063(CHEMBL4287506 | US10550080, Example 45)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin) expressed in HEK293 cells at -40 mV holding potential measured after 600 secs by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465063(CHEMBL4287506 | US10550080, Example 45)
Affinity DataIC50: 59nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465063(CHEMBL4287506 | US10550080, Example 45)
Affinity DataIC50: 26nMAssay Description:hNaV1.7 binding affinities were determined with a filtration binding assay using purified membranes from HEK293 cells stably expressing hNaV1.7. HEK2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465063(CHEMBL4287506 | US10550080, Example 45)
Affinity DataIC50: 3.70E+3nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465063(CHEMBL4287506 | US10550080, Example 45)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells after 600 secs at -50 mV holding potential by ion works barracuda population patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465063(CHEMBL4287506 | US10550080, Example 45)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50465063(CHEMBL4287506 | US10550080, Example 45)
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant mouse Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50465063(CHEMBL4287506 | US10550080, Example 45)
Affinity DataIC50: 24nMAssay Description:Inhibition of Nav1.7 in mouse DRG neurons at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465063(CHEMBL4287506 | US10550080, Example 45)
Affinity DataIC50: 59nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 600 secs at -60 mV holding potential by ion works barracuda population patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed