BDBM50465009 CHEMBL4278921

SMILES COc1ccc(cc1OC)-c1nc(ncc1C(=O)Nc1c(Cl)cncc1Cl)C(F)(F)F

InChI Key InChIKey=NTYCZROBEUBTBF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50465009   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50465009(CHEMBL4278921)
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged PDE4B1 expressed in baculovirus infected Sf9 cells using cAMP as substrate after 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50465009(CHEMBL4278921)
Affinity DataIC50: 281nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged PDE4A1 expressed in baculovirus infected Sf9 cells using cAMP as substrate after 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50465009(CHEMBL4278921)
Affinity DataIC50: 321nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDE3B (592-end residues) expressed in baculovirus infected Sf9 cells using cAMP as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50465009(CHEMBL4278921)
Affinity DataIC50: 89nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDE4A4 (2 to 886 residues) expressed in baculovirus infected Sf9 cells using cAMP as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50465009(CHEMBL4278921)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE4C1 expressed in baculovirus infected Sf9 cells using cAMP as substrate after 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50465009(CHEMBL4278921)
Affinity DataIC50: 360nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDE4D7 (2 to 748 residues) expressed in baculovirus infected Sf9 cells using cAMP as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50465009(CHEMBL4278921)
Affinity DataIC50: 245nMAssay Description:Inhibition of PDE11A (unknown origin) using cAMP as substrate after 1 hr by LANCE TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50465009(CHEMBL4278921)
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE4B1 expressed in baculovirus infected Sf9 cells using cAMP as substrate after 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed