BDBM50464959 CHEMBL4280336

SMILES C[C@H](NC(=O)Cc1cccc(Oc2ccccc2)c1)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1

InChI Key InChIKey=OZHHPGUIBLNCOB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50464959   

TargetProteasome subunit beta type-1(Human)
University of Rennes 1

Curated by ChEMBL
LigandPNGBDBM50464959(CHEMBL4280336)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human 20S constitutive proteasome beta-1 using Z-LLE-betaNA as substrate incubated for 15 mins measured for 45 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
University of Rennes 1

Curated by ChEMBL
LigandPNGBDBM50464959(CHEMBL4280336)
Affinity DataIC50: 350nMAssay Description:Inhibition of human 20S constitutive proteasome beta-5 using Suc-LLVY-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
University of Rennes 1

Curated by ChEMBL
LigandPNGBDBM50464959(CHEMBL4280336)
Affinity DataIC50: 1.62E+4nMAssay Description:Inhibition of human 20S constitutive proteasome beta-2 using BocLRR-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
University of Rennes 1

Curated by ChEMBL
LigandPNGBDBM50464959(CHEMBL4280336)
Affinity DataIC50: 1.43E+4nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using BocLRR-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
University of Rennes 1

Curated by ChEMBL
LigandPNGBDBM50464959(CHEMBL4280336)
Affinity DataIC50: 260nMAssay Description:Inhibition of human 20S immunoproteasome beta-5 using Suc-LLVY-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-9(Human)
University of Rennes 1

Curated by ChEMBL
LigandPNGBDBM50464959(CHEMBL4280336)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human 20S immunoproteasome beta-1 using Ac-PAL-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed