BDBM50464784 CHEMBL4290541

SMILES COc1cc2CCN(CCCCN3C\C(=N/NC(=S)N(C)C)c4ccccc34)Cc2cc1OC

InChI Key InChIKey=LOWGUFRIBOARHL-UHFFFAOYSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50464784   

TargetATP-dependent translocase ABCB1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50464784(CHEMBL4290541)
Affinity DataEC50:  3.04E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK-MDR1 cells assessed as calcein cell accumulation after 30 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50464784(CHEMBL4290541)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-DTG from sigma2 receptor in rat liver membranes in presence of (+)-pentazocine by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed