BDBM50464769 CHEMBL4290098

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])ccc(-[#6](=O)-[#6@@H]-2-[#6@H](-[#6]-[#6](-[#6])=[#6]-[#6@H]-2-c2c(-[#8])cc(-[#8])c3c2oc(c(-[#6]\[#6]=[#6](\[#6])-[#6])c3=O)-c2ccc(-[#8])cc2-[#8])-c2ccc(-[#8])cc2-[#8])c1-[#8]

InChI Key InChIKey=PHNIIIBGRKZKSS-UHFFFAOYSA-N

Data  1 KI  6 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50464769   

TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50464769(CHEMBL4290098)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpA using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50464769(CHEMBL4290098)
Affinity DataKd:  850nMAssay Description:Binding affinity to Mycobacterium tuberculosis PtpB by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50464769(CHEMBL4290098)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to Mycobacterium tuberculosis PtpB by UV-VIS spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50464769(CHEMBL4290098)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of LYP (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured every ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50464769(CHEMBL4290098)
Affinity DataIC50: 360nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpB using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50464769(CHEMBL4290098)
Affinity DataIC50: 5.22E+3nMAssay Description:Inhibition of PTP-PEST (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50464769(CHEMBL4290098)
Affinity DataIC50: 363nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpB using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50464769(CHEMBL4290098)
Affinity DataIC50: 2.54E+3nMAssay Description:Inhibition of human PTP1B using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured every minute fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50464769(CHEMBL4290098)
Affinity DataKi:  200nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpB using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed