BDBM50464617 CHEMBL4284737::US11091476, Example 34

SMILES CCC1(C)C(C)=Nc2ccc(cc12)-c1nc(Nc2ccc(cn2)N2CCN(C)CC2)ncc1F

InChI Key InChIKey=INUMHURQTSNMFM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50464617   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464617(CHEMBL4284737 | US11091476, Example 34)
Affinity DataIC50: 35nMAssay Description:Inhibition of CDK4/Cyclin-D1 (unknown origin) using histone-H1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464617(CHEMBL4284737 | US11091476, Example 34)
Affinity DataIC50: 112nMAssay Description:Inhibition of CDK1/Cyclin-A2 (unknown origin) using histone-H1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464617(CHEMBL4284737 | US11091476, Example 34)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin) using histoneH1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G1/S-specific cyclin- 2(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464617(CHEMBL4284737 | US11091476, Example 34)
Affinity DataIC50: 112nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464617(CHEMBL4284737 | US11091476, Example 34)
Affinity DataIC50: 5.13nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
Go to US Patent