BDBM50464559 CHEMBL4277126::US10464907, Compound 14i::US10889552, Compound 16a

SMILES CN(Cc1cccc(C)c1)C(=O)c1cc(Cl)c(O)cc1O

InChI Key InChIKey=JTJUJIMEPQBPDV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50464559   

TargetHeat shock protein HSP 90-alpha(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50464559(CHEMBL4277126 | US10464907, Compound 14i | US10889...)
Affinity DataIC50: 830nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Bovine)
Industry Academic Cooperation Foundation Keimyung University

US Patent
LigandPNGBDBM50464559(CHEMBL4277126 | US10464907, Compound 14i | US10889...)
Affinity DataIC50: 995nMAssay Description:Fluorescence polarization assay was performed to confirm the binding ability to the compound synthesized with HSP90 according the concentration. 1 M ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50464559(CHEMBL4277126 | US10464907, Compound 14i | US10889...)
Affinity DataIC50: 830nMAssay Description:Endonuclease activity assays were carried out in Black Costar 96-well plates. Each well contained a total volume of 100 μL comprised of: buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent