BDBM50464499 CHEMBL4288319

SMILES Fc1ccc(cc1F)C(=O)OC1=CS(=O)(=O)Nc2ccc(Oc3ccccc3Br)cc12

InChI Key InChIKey=ZCQLLKXWSFUGPP-UHFFFAOYSA-N

Data  4 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50464499   

TargetGenome polyprotein(Dengue virus)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50464499(CHEMBL4288319)
Affinity DataIC50: 600nMAssay Description:Inhibition of DENV3 NS5 RdRp using ss-RNA PolyC as template and GTP as substrate assessed as decrease in dsRNA levels after 1 hr by PicoGreen-based f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetGenome polyprotein(Dengue virus)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50464499(CHEMBL4288319)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to DENV3 NT-647-NHS labeled NS5 RdRp after 1 hr by microscale thermophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetGenome polyprotein(Dengue virus)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50464499(CHEMBL4288319)
Affinity DataKi:  252nMAssay Description:Mixed type inhibition of DENV3 NS5 RdRp using increasing concentration of GTP as substrate assessed as free enzyme after 1 hr in presence of ss-RNA P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetGenome polyprotein(Dengue virus)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50464499(CHEMBL4288319)
Affinity DataKi:  1.54E+3nMAssay Description:Mixed type inhibition of DENV3 NS5 RdRp using increasing concentration of ss-RNA PolyC as template assessed as free enzyme after 1 hr in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetGenome polyprotein(Dengue virus)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50464499(CHEMBL4288319)
Affinity DataKi:  1.58E+3nMAssay Description:Mixed type inhibition of DENV3 NS5 RdRp using increasing concentration of GTP as substrate assessed as enzyme-substrate complex after 1 hr in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetGenome polyprotein(Dengue virus)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50464499(CHEMBL4288319)
Affinity DataKi:  4.33E+3nMAssay Description:Mixed type inhibition of DENV3 NS5 RdRp using increasing concentration of ss-RNA PolyC as template assessed as enzyme-substrate complex after 1 hr in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed