BDBM50464486 CHEMBL4293214

SMILES [O-][N+](=O)c1cc(c(cc1F)-c1ccccc1COc1cccc(c1)C(F)(F)F)[N+]([O-])=O

InChI Key InChIKey=PJMBAGIEJSKTII-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50464486   

TargetProstaglandin G/H synthase 1(Sheep)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50464486(CHEMBL4293214)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by UPLC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50464486(CHEMBL4293214)
Affinity DataIC50: 540nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomes using PGH2 as substrate assessed as reduction in PGE2 production preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed