BDBM50463909 CHEMBL4245579

SMILES CN(C)CCNC(=O)c1c2c(C(=O)c3cccnc3C2=O)n2ccccc12

InChI Key InChIKey=LUEJXSYGNUDXNK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50463909   

TargetTryptophan 2,3-dioxygenase(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50463909(CHEMBL4245579)
Affinity DataIC50: 7.15E+3nMAssay Description:Inhibition of recombinant TDO (unknown origin) assessed as reduction in N-formylkynurenine formation using L-Tryptophan as substrate after 75 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50463909(CHEMBL4245579)
Affinity DataIC50: 188nMAssay Description:Inhibition of IDO1 (unknown origin) assessed as reduction in N'-formlylkynurenine formation using D-Tryptophan as substrate in presence of aspartate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50463909(CHEMBL4245579)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of IFN-gamma-stimulated IDO1 in human HeLa cells after 24 hrs by Ehrlich's reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed