BDBM50463722 CHEMBL4238186

SMILES O=C(Nc1ccc(cc1)N1CCC(CC1)C(=O)N1CCOCC1)c1cnc(Oc2ccccc2)nc1

InChI Key InChIKey=NLSSUSRERAMBTA-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50463722   

TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataKd:  0.370nMAssay Description:Binding affinity to full length recombinant human N-terminal His6-tagged H-PGDS expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50: 71nMAssay Description:Inhibition of recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 3 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50: 320nMAssay Description:Binding affinity to recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50: 83nMAssay Description:Inhibition of recombinant human HPGDS using [14C]-PGH2 as substrate preincubated for 1 min in presence of MgCl2 followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50: 170nMAssay Description:Inhibition of H-PGDS (unknown origin) using fluorescent probe by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50: 211nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed