BDBM504625 N-(3- fluorophenyl)-3- methyl-N-((5-(5- (trifluoromethyl)- 1,2,4-oxadiazol-3- yl)pyridin-2- yl)methyl) pyrazine-2- carboxamide::US11066396, Example 56

SMILES Cc1nccnc1C(=O)N(Cc1ccc(cn1)-c1noc(n1)C(F)(F)F)c1cccc(F)c1

InChI Key InChIKey=LRACOFKZUYQOAU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 504625   

TargetHistone deacetylase 6(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504625(N-(3- fluorophenyl)-3- methyl-N-((5-(5- (trifluoro...)
Affinity DataIC50: 8.20nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504625(N-(3- fluorophenyl)-3- methyl-N-((5-(5- (trifluoro...)
Affinity DataIC50: 250nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504625(N-(3- fluorophenyl)-3- methyl-N-((5-(5- (trifluoro...)
Affinity DataIC50: 3.10E+3nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent