BDBM50462391 CHEMBL4238142

SMILES COc1ccc(Cn2nnc(O)c2C(=O)Nc2cccc(c2)C(F)(F)F)cc1OC

InChI Key InChIKey=LRYULQNWTCDVFL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50462391   

TargetAldo-keto reductase family 1 member C2(Human)
University of Torino

Curated by ChEMBL
LigandPNGBDBM50462391(CHEMBL4238142)
Affinity DataIC50: 1.08E+5nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
University of Torino

Curated by ChEMBL
LigandPNGBDBM50462391(CHEMBL4238142)
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
University of Torino

Curated by ChEMBL
LigandPNGBDBM50462391(CHEMBL4238142)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human COX2 assessed as reduction in PGF2alpha production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Torino

Curated by ChEMBL
LigandPNGBDBM50462391(CHEMBL4238142)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGF2alpha production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed