BDBM50462187 CHEMBL4242050

SMILES CC(C)n1nc(C#Cc2c(C)ccc3cc(ncc23)-c2cccc(c2)C(F)(F)F)c2c(N)ncnc12

InChI Key InChIKey=BCQMLQGCVHMBRI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50462187   

TargetSerine/threonine-protein kinase B-raf(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50462187(CHEMBL4242050)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in cell proliferation incubated for 96 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50462187(CHEMBL4242050)
Affinity DataIC50: 435nMAssay Description:Inhibition of BCR-ABL (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50462187(CHEMBL4242050)
Affinity DataIC50: 44nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) after 20 mins by immunoblotting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50462187(CHEMBL4242050)
Affinity DataIC50: 10nMAssay Description:Inhibition of ABL (unknown origin) by phosphocellulose paper disk assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed