BDBM50461396 CHEMBL4228090

SMILES CNC(=O)c1ccc(Sc2ccc(NC(=S)Nc3cccc(c3)C(F)(F)F)cc2)nc1

InChI Key InChIKey=ORBUKABGOHNTAZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50461396   

TargetSerine/threonine-protein kinase B-raf(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50461396(CHEMBL4228090)
Affinity DataIC50: 571nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) using MEK1 as substrate measured after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50461396(CHEMBL4228090)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR2 (unknown origin) using FAM-labelled peptide as substrate pretreated for 10 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50461396(CHEMBL4228090)
Affinity DataIC50: 503nMAssay Description:Inhibition of B-Raf (unknown origin) using MEK1 as substrate measured after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed