BDBM50461320 CHEMBL4227666

SMILES Cc1noc(C)c1CCNC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1

InChI Key InChIKey=JWFOLANTFTXARN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50461320   

TargetBeta-adrenergic receptor kinase 1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50461320(CHEMBL4227666)
Affinity DataIC50: 640nMAssay Description:Inhibition of GRK2 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetRhodopsin kinase GRK1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50461320(CHEMBL4227666)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50461320(CHEMBL4227666)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of GRK5 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed