BDBM50460829 CHEMBL4225246::US11116757, No. A30

SMILES CC(C)(C)CCN1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=HOTCNXBIXBGORB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50460829   

TargetDCN1-like protein 1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50460829(CHEMBL4225246 | US11116757, No. A30)
Affinity DataIC50: 170nMAssay Description:Binding affinity biotinylated human GST-tagged DCN1 assessed as inhibition of protein interaction with AlexaFluor 488-tagged and N-terminally acetyla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Human)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50460829(CHEMBL4225246 | US11116757, No. A30)
Affinity DataIC50: 178nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Human)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50460829(CHEMBL4225246 | US11116757, No. A30)
Affinity DataIC50: 180nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent