BDBM50460788 CHEMBL4226969

SMILES COc1cccc(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cn[nH]c3)sn2)n1

InChI Key InChIKey=BOZCXHJHINBWSL-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50460788   

TargetAurora kinase A(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50460788(CHEMBL4226969)
Affinity DataIC50: 4nMAssay Description:Inhibition of Aurora A (unknown origin) using Tamra-PKAtide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50460788(CHEMBL4226969)
Affinity DataEC50:  356nMAssay Description:Inhibition of Aurora B in human HCT116 cells assessed as reduction in phosphorylation of Histone H3 at Ser10 residue incubated for 1 hr by Hoechst 33...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50460788(CHEMBL4226969)
Affinity DataIC50: 13nMAssay Description:Inhibition of Aurora B (unknown origin) using Tamra-PKAtide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed