BDBM50460517 CHEMBL4227185

SMILES CC(\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)C1(SCCCS1)[C@H]1CC(=O)O[C@@H]1CO[Si](C)(C)C(C)(C)C

InChI Key InChIKey=OZQXCGAIIGNFTB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50460517   

TargetHistone deacetylase 1(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460517(CHEMBL4227185)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presence of DTT by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460517(CHEMBL4227185)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human placenta topoisomerase 2alpha assessed as reduction in pBR322 supercoiled DNA relaxation after 30 mins by ethidium bromide staini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed