BDBM50460104 CHEMBL4224807

SMILES CN([C@@H]1CCN(C1)C(=O)CC#N)c1ncnc2[nH]ccc12

InChI Key InChIKey=NSQLMHCVPLHMQU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50460104   

TargetTyrosine-protein kinase JAK2(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50460104(CHEMBL4224807)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant human JAK2 (808-end residues) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50460104(CHEMBL4224807)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human JAK1 (866-end residues) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50460104(CHEMBL4224807)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human TYK2 (875-end residues) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50460104(CHEMBL4224807)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant human JAK3 (781-end residues) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50460104(CHEMBL4224807)
Affinity DataIC50: 9.30E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed