BDBM50459944 CHEMBL4225537

SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(CC2)C#N)C(C)(C)C)cc1

InChI Key InChIKey=NDVQUNZCNAMROD-UHFFFAOYSA-N

Data  3 IC50  10 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50459944   

TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataKd:  99nMAssay Description:Binding affinity to VBC (unknown origin) at 50 uM at 10 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataKd:  52nMAssay Description:Binding affinity to VBC (unknown origin) at 50 uM at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataKd:  80nMAssay Description:Displacement of FAM-labeled HIF-1alpha peptide from VBC (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataKd:  90nMAssay Description:Binding affinity to VHL (unknown origin)/elongin C (unknown origin)/elongin B (unknown origin) by isothermal titration calorimetry-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataKd:  90nMAssay Description:Binding affinity to VHL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataIC50: 88nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataKd:  58nMAssay Description:Displacement of FAM-labeled HIF-1alpha peptide from VCB (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataKd:  90nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constant by calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataKd:  90nMAssay Description:Binding affinity to VHL/Elongin B/Elongin C (unknown origin) using FAM-DEALA-Hyp-YIPMDDDFQLRSF as substrate assessed as dissociation constant by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataKd:  80nMAssay Description:Binding affinity to VHL/Elongin B/Elongin C (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataKd:  129nMAssay Description:Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues)/Elongin B/Elogin C (unknown origin) using (FAM)-labeled HIF-1alpha peptide as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataIC50: 750nMAssay Description:Inhibition of NanoLuc-fused VHL (unknown origin) transfected in live HEK293 cells using NanoGlo substrate incubated for 30 mins by tracer based NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataIC50: 576nMAssay Description:Inhibition of NanoLuc-fused VHL (unknown origin) transfected in permeabilized HEK293 cells using NanoGlo substrate incubated for 30 mins by tracer ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed