BDBM50459943 CHEMBL4225470

SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1

InChI Key InChIKey=GFNCBUDQFXZVNN-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50459943   

TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459943(CHEMBL4225470)
Affinity DataKd:  44nMAssay Description:Binding affinity to VHL (unknown origin)/elongin C (unknown origin)/elongin B (unknown origin) by isothermal titration calorimetry-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459943(CHEMBL4225470)
Affinity DataKd:  90nMAssay Description:Displacement of FAM-labeled HIF-1alpha peptide from VBC (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459943(CHEMBL4225470)
Affinity DataKd:  16nMAssay Description:Binding affinity to VBC (unknown origin) at 50 uM at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459943(CHEMBL4225470)
Affinity DataKd:  24nMAssay Description:Binding affinity to VBC (unknown origin) at 50 uM at 10 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50459943(CHEMBL4225470)
Affinity DataKd:  44nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed