BDBM50459538 CHEMBL4218203

SMILES Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2ccccc12)-c1ccccc1

InChI Key InChIKey=OWHVQGGLXPNNBI-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50459538   

TargetKallikrein-4(Human)
German Cancer Research Center (Dkfz)

Curated by ChEMBL
LigandPNGBDBM50459538(CHEMBL4218203)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of N-terminal FLAG-tagged and C-terminal His tagged pro-KLK4 (unknown origin) expressed in Escherichia coli in presence of thermolysin pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetKallikrein-6(Human)
German Cancer Research Center (Dkfz)

Curated by ChEMBL
LigandPNGBDBM50459538(CHEMBL4218203)
Affinity DataIC50: 470nMAssay Description:Inhibition of KLK6 (unknown origin) expressed in Pichia pastoris pre-incubated for 10 mins before Boc-ValProArg-AMC substrate addition and measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetKallikrein-13(Human)
German Cancer Research Center (Dkfz)

Curated by ChEMBL
LigandPNGBDBM50459538(CHEMBL4218203)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KLK13 (unknown origin) expressed in Pichia pastoris pre-incubated for 10 mins before Boc-ValProArg-AMC substrate addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetKallikrein-6(Human)
German Cancer Research Center (Dkfz)

Curated by ChEMBL
LigandPNGBDBM50459538(CHEMBL4218203)
Affinity DataIC50: 130nMAssay Description:Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetKallikrein-5(Human)
German Cancer Research Center (Dkfz)

Curated by ChEMBL
LigandPNGBDBM50459538(CHEMBL4218203)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of KLK5 (unknown origin) expressed in Pichia pastoris pre-incubated for 10 mins before Boc-ValProArg-AMC substrate addition and measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetKallikrein-8(Human)
German Cancer Research Center (Dkfz)

Curated by ChEMBL
LigandPNGBDBM50459538(CHEMBL4218203)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KLK8 (unknown origin) expressed in Pichia pastoris pre-incubated for 10 mins before Boc-ValProArg-AMC substrate addition and measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTrypsin(Human)
German Cancer Research Center (Dkfz)

Curated by ChEMBL
LigandPNGBDBM50459538(CHEMBL4218203)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of trypsin (unknown origin) pre-incubated for 30 mins before N-Boc-FSR-AMC substrate addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetKallikrein-7(Human)
German Cancer Research Center (Dkfz)

Curated by ChEMBL
LigandPNGBDBM50459538(CHEMBL4218203)
Affinity DataIC50: 7.30E+4nMAssay Description:Inhibition of KLK7 (unknown origin) expressed in Pichia pastoris pre-incubated for 10 mins before Leu-Leu-Val-Tyr-AMC substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetKallikrein-14(Human)
German Cancer Research Center (Dkfz)

Curated by ChEMBL
LigandPNGBDBM50459538(CHEMBL4218203)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of KLK14 (unknown origin) expressed in Pichia pastoris pre-incubated for 10 mins before Boc-ValProArg-AMC substrate addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed