BDBM50459310 CHEMBL4207168::US12122799, Compound JXW-572

SMILES ON(C\C=C\P(O)([O-])=O)C=O

InChI Key InChIKey=YTTBDWKRMPYBDN-UHFFFAOYSA-M

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50459310   

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50459310(CHEMBL4207168 | US12122799, Compound JXW-572)
Affinity DataIC50: 92nMAssay Description:Inhibition of Plasmodium falciparum DXR assessed as reduction in NADPH oxidation in presence of DOXP by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Staphylococcus hyicus subsp. chromogenes)
The George Washington University

US Patent
LigandPNGBDBM50459310(CHEMBL4207168 | US12122799, Compound JXW-572)
Affinity DataIC50: 170nMAssay Description:Oxidation of NADPH to NADP+ as a result of substrate turnover was monitored at 340 nm in a POLARstar Omega microplate reader (BMG Labtech). The stand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
Go to US Patent

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase()
The George Washington University

US Patent
LigandPNGBDBM50459310(CHEMBL4207168 | US12122799, Compound JXW-572)
Affinity DataIC50: 410nMAssay Description:Oxidation of NADPH to NADP+ as a result of substrate turnover was monitored at 340 nm in a POLARstar Omega microplate reader (BMG Labtech). The stand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
Go to US Patent