BDBM50459106 CHEMBL4203445

SMILES CO[C@@H]1C[C@H](N(Cc2cc(Cl)ccc2Cl)C1)C(=O)N1CCN(C2CC2)c2ccccc12

InChI Key InChIKey=YKEKXUZALGCYOY-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50459106   

TargetG-protein coupled bile acid receptor 1(Mouse)
Ardelyx

Curated by ChEMBL
LigandPNGBDBM50459106(CHEMBL4203445)
Affinity DataEC50:  100nMAssay Description:Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Ardelyx

Curated by ChEMBL
LigandPNGBDBM50459106(CHEMBL4203445)
Affinity DataEC50:  126nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed