BDBM50458819 CHEMBL4213725

SMILES CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(CC=CCCCCCCC(=O)N[C@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N1)c2)C(=O)N[C@@H](CC(C)C)C(O)=O

InChI Key InChIKey=PJDKVHXZLHUPET-UHFFFAOYSA-N

Data  1 KI  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50458819   

TargetNeurotensin receptor type 1(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50458819(CHEMBL4213725)
Affinity DataIC50: 26nMAssay Description:Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50458819(CHEMBL4213725)
Affinity DataEC50:  1.37E+3nMAssay Description:Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50458819(CHEMBL4213725)
Affinity DataEC50:  433nMAssay Description:Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50458819(CHEMBL4213725)
Affinity DataEC50:  166nMAssay Description:Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50458819(CHEMBL4213725)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50458819(CHEMBL4213725)
Affinity DataKi:  5.60E+3nMAssay Description:Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed