BDBM50458640 CHEMBL4203934

SMILES CCN1CC(C(=O)NC(C)CCc2ccc(Cl)c(Cl)c2)=C(O)C1=O

InChI Key InChIKey=ALSUALXMUDUBLA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50458640   

TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458640(CHEMBL4203934)
Affinity DataIC50: 148nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458640(CHEMBL4203934)
Affinity DataIC50: 44nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458640(CHEMBL4203934)
Affinity DataIC50: 264nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using HDL as substrate pretreated for 10 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEndothelial lipase(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458640(CHEMBL4203934)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant mouse endothelial lipase expressed in HEK293F cells using HDL as substrate pretreated for 10 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458640(CHEMBL4203934)
Affinity DataIC50: 218nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using HDL as substrate pretreated for 10 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458640(CHEMBL4203934)
Affinity DataIC50: 218nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using HDL as substrate pretreated for 10 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458640(CHEMBL4203934)
Affinity DataIC50: 148nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458640(CHEMBL4203934)
Affinity DataIC50: 218nMAssay Description:Inhibition of recombinant human endothelial lipase expressed in African green monkey COS7 cells using HDL as substrate pretreated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458640(CHEMBL4203934)
Affinity DataIC50: 4.76E+5nMAssay Description:Inhibition of endothelial lipase (unknown origin) using D31-POPC-HDL as substrate after 2 hrs in presence of human serum by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed