BDBM50458617 CHEMBL4215835

SMILES CC(CC(O)=O)c1cccc(n1)-n1c(cc2ccc(OC(F)(F)F)cc12)C(N)=O

InChI Key InChIKey=FWKHYTJUMWATOO-UHFFFAOYSA-N

Data  18 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50458617   

TargetCytochrome P450 2C19(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C19More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
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TargetPhospholipase A2 group V(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of sPLA2-5 (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substra...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetGroup 10 secretory phospholipase A2(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 14nMAssay Description:Inhibition of sPLA2-10 (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetPhospholipase A2, membrane associated(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 630nMAssay Description:Inhibition of sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetCytochrome P450 2C8(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C8More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetCytochrome P450 2D6(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetPotassium voltage-gated channel subfamily D member 3(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human Kv4.3 expressed in CHO cells by ionworks patch clamp assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human Cav1.2 expressed in CHO cells by ionworks patch clamp assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetGroup 10 secretory phospholipase A2(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 14nMAssay Description:Inhibition of sPLA2-10 (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by ionworks patch clamp assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetSodium channel protein type 5 subunit alpha(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human Nav1.5 expressed in CHO cells by ionworks patch clamp assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human Cav3.2 expressed in CHO cells by ionworks patch clamp assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetCytochrome P450 2C9(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C9More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetCytochrome P450 1A2(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP1A2More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetGroup 10 secretory phospholipase A2(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 42nMAssay Description:Inhibition of recombinant human sPLA2-10 using human HDL as substrate pretreated for 20 mins followed by substrate addition and measured after 60 min...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetGroup 10 secretory phospholipase A2(Mouse)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 75nMAssay Description:Inhibition of mouse sPLA2-10More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhospholipase A2, membrane associated(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50458617(CHEMBL4215835)Copy SMILESCopy InChI

Affinity DataIC50: 630nMAssay Description:Inhibition of sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL