BDBM50458609 CHEMBL4213094

SMILES NC(=O)c1cc2ccc(OC(F)(F)F)cc2n1-c1cc(CCC(O)=O)ccn1

InChI Key InChIKey=KEQSTBYHFUWBLB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50458609   

TargetGroup 10 secretory phospholipase A2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50458609(CHEMBL4213094)
Affinity DataIC50: 110nMAssay Description:Inhibition of sPLA2-10 (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhospholipase A2, membrane associated(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50458609(CHEMBL4213094)
Affinity DataIC50: 290nMAssay Description:Inhibition of sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhospholipase A2 group V(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50458609(CHEMBL4213094)
Affinity DataIC50: 720nMAssay Description:Inhibition of sPLA2-5 (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGroup 10 secretory phospholipase A2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50458609(CHEMBL4213094)
Affinity DataIC50: 640nMAssay Description:Inhibition of recombinant human sPLA2-10 using human HDL as substrate pretreated for 20 mins followed by substrate addition and measured after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed