BDBM50458543 CHEMBL4208079::US11999723, Compound 8x

SMILES OC(=O)c1cc(ccc1Oc1cccc(c1)-c1ccc(OCCCN2CCOCC2)cc1)-c1c[nH]nc1F

InChI Key InChIKey=UZPKKLQXQXQEBE-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50458543   

TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50458543(CHEMBL4208079 | US11999723, Compound 8x)
Affinity DataKi:  67nMAssay Description:Inhibition of recombinant human MIF expressed in Escherichia coli using HPP as substrate preincubated for 20 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50458543(CHEMBL4208079 | US11999723, Compound 8x)
Affinity DataKi:  67nMAssay Description:Inhibition of the tautomerase activity of MIF was measured using the substrate 4-hydroxyphenyl pyruvic acid (HPP) in a procedure largely adapted from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2024
Entry Details
Go to US Patent