BDBM50458539 CHICAGO SKY BLUE SODIUM::Chicago Sky Blue::Chicago Sky Blue 6B

SMILES COc1cc(ccc1\N=N\c1ccc2c(cc(c(N)c2c1O)S([O-])(=O)=O)S([O-])(=O)=O)-c1ccc(\N=N\c2ccc3c(cc(c(N)c3c2O)S([O-])(=O)=O)S([O-])(=O)=O)c(OC)c1

InChI Key InChIKey=OHMJKMNGYYWCHB-UHFFFAOYSA-J

Data  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50458539   

TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50458539(CHICAGO SKY BLUE SODIUM | Chicago Sky Blue | Chica...)
Affinity DataIC50: 810nMAssay Description:Inhibition recombinant human biotin-labeled MIF binding to recombinant human soluble CD47 receptor (73 to 232 residues) preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
France

Curated by ChEMBL
LigandPNGBDBM50458539(CHICAGO SKY BLUE SODIUM | Chicago Sky Blue | Chica...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa IMPDH using IMP as substrate in the presence of NAD+ incubated for 70 secsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50458539(CHICAGO SKY BLUE SODIUM | Chicago Sky Blue | Chica...)
Affinity DataIC50: 810nMAssay Description:Inhibition of recombinant biotinylated human MIF expressed in Escherichia coli BL21 DE3 binding to immobilized soluble human CD74 receptor ectodomain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50458539(CHICAGO SKY BLUE SODIUM | Chicago Sky Blue | Chica...)
Affinity DataKd:  9.04E+3nMAssay Description:Binding affinity to recombinant biotinylated human MIF expressed in Escherichia coli BL21 DE3 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50458539(CHICAGO SKY BLUE SODIUM | Chicago Sky Blue | Chica...)
Affinity DataIC50: 370nMAssay Description:Inhibition of recombinant biotinylated human MIF tautomerase activity expressed in Escherichia coli BL21 DE3 assessed as reduction in tautomerization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50458539(CHICAGO SKY BLUE SODIUM | Chicago Sky Blue | Chica...)
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant human MIF expressed in Escherichia coli BL21 DE3 binding to recombinant soluble human CD74 receptor ectodomain (73 to 232 r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50458539(CHICAGO SKY BLUE SODIUM | Chicago Sky Blue | Chica...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of MIF-induced IL-8 secretion in human foreskin fibroblasts incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed